Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction ( K i : 11.7 μM). Antifungal agent 72 is active against Fluconazole ( HY-B0101 )-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole . Antifungal agent 72 can be used for C. glabrata infection research.
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