PROTAC BRD4 Degrader-22 is a BRD4 PROTAC degrader with a DC 50 of 0.59 nM. At high concentrations, PROTAC BRD4 Degrader-22 induces partial degradation of BRD3 and BRD2 , but exhibits selectivity for IKZF3 . PROTAC BRD4 Degrader-22 can be used in leukemia-related research. (Pink: BRD4 ligand ( HY-78695 ); Blue: Cereblon ligand ( HY-W879795 ); Black: linker ( HY-W010525 )).
Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain
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