JTE-151

Overview

JTE-151 is an orally active, selective RORγ antagonist with IC 50 values of 20.6 nM, 41.8 nM and 32.2 nM against hRORγ, rRORγ and mRORγ, respectively . JTE-151 reduces the production of IL-17 . JTE-151 alleviates paw swelling and bone destruction in arthritis models. JTE-151 can be used in research related to rheumatoid arthritis, collagen-induced arthritis, experimental autoimmune encephalomyelitis, psoriasis, multiple sclerosis and inflammatory bowel disease.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Arthritis | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Multiple Sclerosis | Products > Disease Areas > Psoriasis | Products > Disease Areas > Inflammatory Bowel Disease | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-155487
• CAS No.: 1404380-58-0
• Molecular Formula: C28H37ClN2O4
• Molecular Weight: 501.06
• Purity: 99.34%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source