SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 M pro inhibitor ( IC 50 =0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication ( EC 50 =1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects ( CC 50 >50 μM).
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