SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti- SARS-CoV-2 activity ( EC 50 = 0.18 μM) and low cytotoxicity ( CC 50 > 50 μM) in Vero E6 cells.
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