Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase ( CYP51 ). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
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