NPD-2975

Overview

NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection . NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC 50 0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC 50 values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19 , respectively.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-155732
• CAS No.: 3032452-65-3
• Molecular Formula: C14H13FN4O
• Molecular Weight: 272.28
• Purity: 98.40%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source