PHD-IN-1 (compound 80) is a potent inhibitor of PHD2,with an IC 50 value of ≤5 nM. PHD-IN-1 shows EC 50 s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells,respectively.
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