Leukadherin-1

Overview

Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18 , increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC 50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.

Application

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Product Information

• Catalog No.: HY-15701
• CAS No.: 344897-95-6
• Molecular Formula: C22H15NO4S2
• Molecular Weight: 421.49
• Purity: 98.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 10 mg/mL (23.73 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source