AP736

Overview

AP736 is a potent tyrosinase inhibitor ( IC 50 = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes ( IC 50 = 0.11 μM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP- PKA -CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Others | Products > Signaling Pathways > Tyrosinase | Products > Signaling Pathways > PKA

Product Information

• Catalog No.: HY-157010
• CAS No.: 1365531-21-0
• Molecular Formula: C26H31NO5
• Molecular Weight: 437.53
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source