Nampt activator-4

Overview

Nampt activator-4 is an orally active NAMPT activator, with an EC 50 of 58 nM and a K a of 85.38 nM against human NAMPT . Nampt activator-4 effectively relieves the feedback inhibition of nicotinamide and NAD + , thereby enhancing enzymatic activity and significantly increasing intracellular NAD + levels. Nampt activator-4 exhibits moderate stability in human and mouse liver microsomes. Nampt activator-4 shows low to moderate inhibitory effects on cytochrome P450 (especially CYP3A4 ). Nampt activator-4 can be used for the research of type 2 diabetes and related metabolic disorders.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > NAMPT

Product Information

• Catalog No.: HY-157421
• CAS No.: 2847156-05-0
• Molecular Formula: C26H22F3N7OS
• Molecular Weight: 537.56
• Purity: 98.87%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution
• Availability: In-stock

Source

Original product source