UNC9036

Overview

UNC9036 is a STING PROTAC degrader with a DC 50 value of 227 nM. UNC9036 binds to and activates STING , recruits the VHL E3 ligase to target phosphorylated STING for ubiquitination and proteasomal degradation. UNC9036 inhibits downstream innate immune signaling events triggered by cytoplasmic DNA sensing, including IRF3 phosphorylation. UNC9036 reduces the antiviral response of cells infected with HSV-1 . UNC9036 can be used in the research of renal cell carcinoma. (Pink: STING ligand ( HY-184545 ); Blue: VHL ligand ( HY-138678B ); Black: linker ( HY-W105727 )).

Application

Products | Products > Disease Areas > Viral Infection | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > HSV Infection | Products > Disease Areas > Renal Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STING | Products > Signaling Pathways > HSV

Product Information

• Catalog No.: HY-158048
• CAS No.: 3094059-54-5
• Molecular Formula: C73H95N17O11S
• Molecular Weight: 1418.71
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source