FGFR1 inhibitor-11 (compound 5g) binds to FGFR 1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > FGFR
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