MY-1B

Overview

MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 ( IC 50 : 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2 . MY-1B can stereoselectively and covalently bind to PSME1 , disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes.

Application

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Product Information

• Catalog No.: HY-158301
• CAS No.: 2929308-79-0
• Molecular Formula: C22H18BrN3O2
• Molecular Weight: 436.30
• Purity: 99.94%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution
• Availability: In-stock

Source

Original product source