Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL , which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation ( IC 50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Endocrinology | Products > Signaling Pathways > RANKL/RANK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NF-κB
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