PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL , thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib ( HY-50856 ), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment.
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