SIK-IN-1

Overview

SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase ( SIK ), which inhibits SIK1 , SIK2 and SIK3 with IC 50 s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC 50 of 0.5 nM, stimulates the LPS ( HY-D1056 ) -induced IL-10 release with EC 50 of 4 nM in human macrophages.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > AMPK

Product Information

• Catalog No.: HY-161440
• CAS No.: 3033846-29-3
• Molecular Formula: C23H24N6OS
• Molecular Weight: 432.54
• Purity: 98.91%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution
• Availability: In-stock

Source

Original product source