PROTAC SMARCA2 degrader-8

Overview

PROTAC SMARCA2 degrader-8 is a SMARCA2 PROTAC degrader with a DC 50 of 28 nM in A375 cells. PROTAC SMARCA2 degrader-8 forms a crystallizable ternary complex with the SMARCA4 bromodomain and VBC, promoting the ubiquitination and proteasomal degradation of SMARCA2 . PROTAC SMARCA2 degrader-8 can be used in melanoma research. (Pink: Target protein ligand; Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Melanoma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-161882
• CAS No.: 2669027-50-1
• Molecular Formula: C43H50N10O5S
• Molecular Weight: 818.99
• Purity: 99.54%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.05 mM); Clear solution
• Availability: In-stock

Source

Original product source