NF-κB-IN-14

Overview

NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages ( IC 50 : 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Toll-like Receptor (TLR)

Product Information

• Catalog No.: HY-162004
• CAS No.: 3019972-01-8
• Molecular Formula: C15H12Cl2N4
• Molecular Weight: 319.19
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source