Cap-dependent endonuclease-IN-27 (Compound 8) is an orally active potent cap-dependent endonuclease ( CEN ) inhibitor. Cap-dependent endonuclease-IN-27, an antiviral agent, shows activity against influenza B virus. Cap-dependent endonuclease-IN-27 has inhibitory activity against IFV A/WSN/33 (H1N1) polymerase ( EC 50 = 12.26 nM).
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