WJ-39 is an orally active aldose reductase ( AR ) inhibitor. WJ-39 improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy , and attenuating apoptosis .
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Autophagy | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Aldose Reductase | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Mitophagy
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