MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS . MS7829 recruits OTUB1 to cGAS , binds covalently to OTUB1 , stabilizes the protein abundance of cGAS , and activates the cGAS - STING - IRF3 innate immune signaling pathway in an OTUB1 -dependent manner. MS7829 is applicable to cancer-related research.
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