aTAG 4531

Overview

aTAG 4531 is a PROTAC -class degrader that induces the degradation of the MTH1/aTAG fusion protein by recruiting cereblon , with a DC 50 of 0.28 nM in Jurkat cells. aTAG 4531 inhibits MTH1 enzymatic activity, with a K i of 1.8 nM. aTAG 4531 rapidly, selectively and reversibly regulates SMART-CAR protein levels, CAR-mediated target cell killing and IL-2 release, and is applicable both in vitro and in vivo. aTAG 4531 can be used in studies of targeted protein degradation, target validation and CAR-T activity regulation. (Pink: MTH1 ligand ( HY-134725 ); Blue: Cereblon ligand ( HY-126457 ); Black: linker ( HY-108374 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-163168
• CAS No.: 2412985-00-1
• Molecular Formula: C46H39F2N9O7
• Molecular Weight: 867.85
• Purity: 99.1%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source