PROTAC SMARCA2/4 degrader-15

Overview

PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4 . PROTAC SMARCA2/4-degrader-15 degrades SMARCA2 in A549 with DC 50 <100 nM, degrades SMARCA4 in MV411 with DC 50 <100 nM (Pink: SMARCA2 and SMARCA4 ligand ( HY-159545 ); Blue: VHL ligand ( HY-125845 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-163868
• CAS No.: 2568276-81-1
• Molecular Formula: C50H55N11O5S
• Molecular Weight: 922.11
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source