Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC 50 of 0.27 nM in A549 cells. (Pink: HDAC8 ligand ( HY-163921 ); Blue: Cereblon ligand ( HY-150799 ); Black: linker).
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HDAC
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