AJI-100

Overview

AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC 50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > Mitosis | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-164454
• CAS No.: 844435-10-5
• Molecular Formula: C17H14FN5O
• Molecular Weight: 323.32
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source