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| ARRY-334543 Basic information |
| Product Name: | ARRY-334543 | | Synonyms: | ARRY-334543;AR-00334543;Varlitinib;(R)-4-[[3-Chloro-4-[(thiazol-2-yl)methoxy]phenyl]amino]-6-[(4-methyl-4,5-dihydrooxazol-2-yl)amino]quinazoline;(R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine;Varlitinib ARRY 334543;ARRY 334543 (Varlitinib);ASLAN001) | | CAS: | 845272-21-1 | | MF: | C22H19ClN6O2S | | MW: | 466.94 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 845272-21-1.mol |
| ARRY-334543 Chemical Properties |
| Boiling point | 637.1±65.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | pka | 6.54±0.70(Predicted) | | CAS DataBase Reference | 845272-21-1 |
| ARRY-334543 Usage And Synthesis |
| Uses | ARRY334543 is a selective and potent ErbB1 and ErbB2 inhibitor with IC50 of 7 nM and 2 nM, respectively. | | Uses | Varlitinib is a tyrosine kinase inhibitor being developed for the treatment of cancer. Varlitinib acts by disrupting the receptor tyrosine kinases ErbB-2, ErbB-4 and EGFR. | | Uses | Varlitinib is a tyrosine kinase inhibitor being developed for the treatment of cancer. Varlitinib acts by disrupting the receptor tyrosine kinases ErbB-2, ErbB-4 and EGFR. | | Enzyme inhibitor | This ErbB1/2 inhibitor (FW = 466.94 g/mol; CAS 845272-21-1), also named (R)-N4 -(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6 -(4-methyl-4,5- dihydrooxazol-2-yl)quinazoline-4,6-diamine, selectively targets the intrinsic protein kinase activities of ErbB1, or Epidermal Growth Factor Receptor (EGFR), IC50 = 7 nM and ErbB2, or Human Epidermal growth factor Receptor (HER2), IC50 = 2 nM. ARRY-334543 also reverses multidrug resistance by antagonizing the activity of ATP-binding cassette subfamily G member 2. |
| ARRY-334543 Preparation Products And Raw materials |
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