Sphingosine (C22-D-erythro-Sphingosine) is a metabolite of sphingolipid and a pro- Apoptotic signaling messenger. Sphingosine induces apoptosis via Caspase -dependent, mitochondria-dependent and lysosomal affinity detergent pathways, downregulates Bcl-2 and Bcl-xL , and truncates Bid and Bax . Sphingosine is used for cancer research.
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