MRS4833 (compound 15) is an orally active, potent, competitive P2Y 14 R antagonist with an of IC 50 of 5.92 nM for hP2Y 14 R and an IC 50 of 4.8 nM for mP2Y 14 R . MRS4833 reduces airway eosinophilia in a protease-mediated asthma model and reverses chronic neuropathic pain in a mouse CCI model.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2Y Receptor
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