Flucopride (Compound 4a) is an AChE inhibitor ( IC 50 : 24 nM), and a partial 5-HT 4 R agonist (K i : 9.6 nM for (h)5-HT4R). Flucopride promotes the non-amyloidogenic processing of APP in COS-7 transiently expressing (h)5-HT 4 R (EC 50 : 23.0 nM). Flucopride may has good gastrointestinal track (GIT) penetration, and blood-brain barrier (BBB) cross-membrane penetration (PAMPA assay).
Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Infection | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > 5-HT Receptor
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