PROTAC BRM/BRG1 degrader-3

Overview

PROTAC BRM/BRG1 degrader-3 is a BRM/BRG1 PROTAC degrader, exhibiting a DC 50 of less than 1 nM for BRM degradation and a DC 50 of greater than 1 nM for BRG1 degradation in SW1573 cells. PROTAC BRM/BRG1 degrader-3 shows moderate inhibitory activity against CYP2D6 and hERG . PROTAC BRM/BRG1 degrader-3 inhibits cancer cell proliferation and tumor tissue growth, and exhibits favorable metabolic stability in liver microsomes. PROTAC BRM/BRG1 degrader-3 can be used in non-small cell lung cancer-related research. (Pink: SMARCA2/BRM/BAF190B/SNF2L2 and SMARCA4/BRG1/BAF190A ligand ( HY-168252 ); Blue: VHL ligand ( HY-168253 ); Black: linker ( HY-69260 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex | Products > Signaling Pathways > Transcription Factor ERG

Product Information

• Catalog No.: HY-168251
• CAS No.: 2933125-05-2
• Molecular Formula: C50H63N11O5S
• Molecular Weight: 930.17
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source