Aurora-A ligand 1

Overview

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K d ) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein ( Ligands for Target Protein for PROTAC ) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 ( HY-168439 ). HLB-0532259 shows anti-tumor activity against neuroblastoma.

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ligands for Target Protein for PROTAC | Products > Signaling Pathways > Aurora Kinase | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-168440
• CAS No.: 2541626-73-5
• Molecular Formula: C21H23N5O3
• Molecular Weight: 393.44
• Purity: 98.75%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source