PROTAC CDK9 degrader-9

Overview

PROTAC CDK9 degrader-9 is an orally active, selective CDK9 PROTAC degrader with a DC 50 of 3.94 nM. PROTAC CDK9 degrader-9 downregulates downstream targets c-Myc and MCL-1 . PROTAC CDK9 degrader-9 inhibits the proliferation of breast cancer cells. PROTAC CDK9 degrader-9 can be used for the research of triple-negative breast cancer . (Pink: CDK9 ligand ( HY-182810 ); Blue: Cereblon ligand ( HY-W998346 ); Black: linker).

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-168518
• CAS No.: 3117192-80-7
• Molecular Formula: C42H51FN12O6
• Molecular Weight: 838.93
• Purity: 99.25%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.98 mM); Clear solution
• Availability: In-stock

Source

Original product source