DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA ( IC 50 =0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC 50 value of 0.83 µM for the inhibition of T. brucei .
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