FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa ( FXIa ) and plasma kallikrein ( PKa ) with an IC 50 of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC 1.5X of 0.55 μM.
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Factor Xa
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