DCN1-IN-2 is a DCN1 inhibitor with an IC 50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ -induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3 .
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > TGF-beta/Smad
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