Lipid C2

CAS No.：3003022-09-8
Grade：99.98%
Formula：C70H142N6O6
M.W.：1163.91

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles ( LNP ) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus ( EBV ) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 ( PD-1 ) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 + CD8 + central and CD3 + CD8 + effector memory T cells and decrease the percentage of CD3 + T cells expressing Pd-1 , in the spleen in a CT26 murine EBV-infected colon cancer model.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Liposome

Product Information

Catalog No.: HY-169480
CAS No.: 3003022-09-8
Molecular Formula: C70H142N6O6
Molecular Weight: 1163.91
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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