SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme ( SMase ) inhibitor ( IC 50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu 2+ in biometal interactions. SMase-IN-1 reduces B. cereus -induced hemolysis on sheep erythrocytes.
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