HNC-1664 is the orally active inhibitor for RNA-dependent RNA polymerase ( RdRP ). HNC-1664 exhibits broad-spectrum antiviral activity against coronavirus (SARS-CoV-2 wildtype and its mutants XBB.1.18, HK.3.1, BF.7.14, BA.1HCoV-229E, HCoV-OC43) and arenavirus . HNC-1664 exhibits anti-infectious activity in SARS-CoV-2 Delta infected mouse models.
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