EP055 is a non-hormonal male contraceptive. EP055 targets to sperm protein EPPIN and inhibits anti-EPPIN antibodies from binding EPPIN with an IC 50 of 1121 μM. EP055 can inhibit sperm motility ( IC 50 = 199.5 μM) by reducing the internal pH and Ca 2+ levels of the sperm, thereby causing the sperm to aggregate. EP055 can be used for development of male contraceptive.
Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Male Reproductive System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Ser/Thr Protease
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