1-Acetyl-DHA (Compound 7) is a substrate of the phosphotriesterase homology protein ( PHP ) and can be hydrolyzed by PHP with a k cat /k m value of 100 M -1 s -1 . The level of 1-Acetyl-DHA is regulated by mTORC1 and is negatively correlated with the nuclear acetate level. 1-Acetyl-DHA plays an important role in cellular metabolism and the regulation of histone acetylation.
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