RIPK2-IN-7 (Compound 10w) is an orally active, selective RIPK2 inhibitor ( IC 50 : 0.6 nM). RIPK2-IN-7 inhibits RIPK2 kinase activity, blocks the nucleotide-binding oligomerization domain (NOD) signaling pathway, and reduces the production of inflammatory factors (such as TNFα). RIPK2-IN-7 can be used in the study of inflammatory bowel disease (IBD).
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > TNF Receptor
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