FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein . FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase , inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS. (Black: Glycolic acid ( HY-W015967 ); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine ( HY-138793 )) (Pink: Target protein ligand; Blue: Cereblon ligand ( HY-138793 ); Black: linker ( HY-W015967 )).
Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > HIV
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