AB-343 is a selective covalent inhibitor of SARS-CoV-2 Mpro, with an IC 50 of 8 nM and a K i of 2.8 nM. AB-343 can effectively inhibit the main proteases of SARS-CoV-2 and many other coronaviruses, and is also active against some resistant variants. AB-343 can be used in the research of treating coronavirus infection-related diseases.
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