PARP14 inhibitor 1 is an orally active, selective PARP14 inhibitor with an IC 50 of 5.52 nM. PARP14 inhibitor 1 exhibits favorable pharmacokinetic properties and in vivo safety. PARP14 inhibitor 1 enhances and stabilizes intracellular endogenous PARP14 protein levels, while effectively reducing the expression levels of IL-4 , IL-13 and IL-17A . PARP14 inhibitor 1 can be used in research related to atopic dermatitis.
Products | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Skin Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Interleukin Related
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