ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator ( IC 50 s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC 50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα , PPARγ and PPARδ ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model.
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