ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity ( IC 50 = 8.3 nM) and high binding affinity ( K D = 72.0 nM) to ACLY . ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect.
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