TYD-68

Overview

TYD-68 is a highly efficient and selective CRBN-recruited TYK2 PROTAC degrader with a DC 50 value of 0.42 nM. TYD-68 significantly inhibits IL-12 and IFN-α -induced STAT4 and STAT1 phosphorylation, thereby blocking TYK2 -dependent signaling pathways. TYD-68 can be used in the study of psoriasis. (Pink: Tyk2 JH2 ligand ( HY-173359 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W007732B )).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > JAK | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-173357
• CAS No.: 3110703-72-2
• Molecular Formula: C43H40FN11O7
• Molecular Weight: 841.85
• Purity: 99.54%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (2.97 mM); Clear solution
• Availability: In-stock

Source

Original product source