β-Glucuronidase-IN-3

Overview

β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) ( IC 50 : 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan ( HY-16562 ) and nonsteroidal anti-inflammatory drugs (NSAIDs).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > β-glucuronidase | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-173397
• CAS No.: 3081681-34-4
• Molecular Formula: C10H7N3OSe
• Molecular Weight: 264.14
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source