STING-IN-15

Overview

STING-IN-15 is an orally active STING inhibitor, with an IC 50 of 116 nM against h-STING and an IC 50 of 96.3 nM against m-STING . STING-IN-15 inhibits the STING signaling pathway in cells, reduces the secretion of IFN-β and IP-10 , downregulates the expression of ISG15 , ISG56 and TNF-α , and suppresses the phosphorylation of TBK1 / IRF3 . STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > STING | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-173425
• CAS No.: 2912492-05-6
• Molecular Formula: C20H14F2N4O3
• Molecular Weight: 396.35
• Purity: 99.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution
• Availability: In-stock

Source

Original product source